Navigating the Landscape of Translational Geroscience in Canada: A Comprehensive Evaluation of Current Progress and Future Directions (2024)

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Volume 79 Issue 7 July 2024
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Guy Hajj-Boutros, MSc

Department of Medicine, McGill University and Research Institute of the McGill University Health Centre

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Montréal, Québec

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Canada

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Andréa Faust, MSc

Department of Medicine, McGill University and Research Institute of the McGill University Health Centre

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Montréal, Québec

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Canada

Schouela Centre of Excellence for Sustainable Health of Seniors (Schouela CEDurable)

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Montreal, Québec

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Canada

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John Muscedere, MD

Canadian Frailty Network

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Kingston, Ontario

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Canada

Department of Critical Care Medicine, Queen’s University

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Kingston, Ontario

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Canada

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Perry Kim, PhD

Canadian Frailty Network

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Kingston, Ontario

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Canada

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Naji Abumrad, MD

Division of Surgical Oncology and Endocrine Surgery, Department of Surgery, Vanderbilt University Medical Center

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Nashville, Tennessee

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USA

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Stéphanie Chevalier, PhD

School of Human Nutrition, McGill University

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Montréal

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Québec

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Canada

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Mylene Aubertin-Leheudre, PhD

Département des Sciences de l’Activité Physique, Faculté des Sciences, Université du Québec à Montréal

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Montréal

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Québec

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Canada

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Howard Bergman, MD

Schouela Centre of Excellence for Sustainable Health of Seniors (Schouela CEDurable)

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Montreal, Québec

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Canada

Department of Family Medicine, Faculty of Medicine and Health Sciences, McGill University

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Montreal

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Québec

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Canada

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Dawn Bowdish, PhD

Department of Pathology and Molecular Medicine, McMaster University

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Hamilton, Ontario

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Canada

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Jessica Burford, RN

Arthur Labatt Family School of Nursing, Faculty of Health Science, Western University

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London, Ontario

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Canada

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Stacy Carrington-Lawrence, PhD

Division of Aging Biology, National Institute on Aging, National Institutes of Health

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Bethesda, Maryland

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USA

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Hélène Côté, PhD

Department of Pathology and Laboratory Medicine, University of British Columbia

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Vancouver, British Columbia

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Canada

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David E Dawe, MD, MSc

Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba

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Winnipeg

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Manitoba

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Canada

Paul Albrechtsen Research Institute, CancerCare Manitoba

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Winnipeg

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Manitoba

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Canada

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Philipe de Souto Barreto, PhD

IHU HealthAge

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CERPOP UMR 1295, Toulouse

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France

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Colin Farrelly, PhD

Department of Political Studies, Queen’s University

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Kingston, Ontario

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Canada

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Robert Fowler, MDCM

Department of Critical Care Medicine, Sunnybrook Health Sciences Centre

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Toronto, Ontario

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Canada

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Gilles Gouspillou, PhD

Département des Sciences de l’Activité Physique, Faculté des Sciences, Université du Québec à Montréal

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Montréal

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Québec

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Canada

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Lea Harrington, PhD

Department of Biochemistry, University of Toronto

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Toronto, Ontario

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Canada

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Sofie Lautrup, PhD

Department of Clinical Molecular Biology, University of Oslo, and Akershus University Hospital

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Lørenskog

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Norway

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Susan Howlett, PhD

Department of Medicine (Geriatric Medicine), Dalhousie University

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Halifax, Nova Scotia

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Canada

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Mahdi Imani, PhD

Australian Institute for Musculoskeletal Science (AIMSS), Geroscience and Osteosarcopenia Research Program, University of Melbourne and Western Health

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St Albans, Victoria

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Australia

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James Kirkland, MD, PhD

Mayo Clinic

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Rochester, Minnesota

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USA

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George Kuchel, MD

UConn Center on Aging, University of Connecticut School of Medicine, UConn Health

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Farmington, Connecticut

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USA

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Frédérick A Mallette, PhD

Department of Medicine, Université de Montréal

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Montréal, Québec

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Canada

Maisonneuve-Rosemont Hospital Research Centre

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Montréal, Québec

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Canada

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José A Morais, MD

Department of Medicine, McGill University and Research Institute of the McGill University Health Centre

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Montréal, Québec

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Canada

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John C Newman, MD, PhD

Buck Institute for Research on Aging

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San Francisco, California

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USA

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Daryl Pullman, PhD

Faculty of Medicine, Memorial University

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St. John’s, Newfoundland

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Canada

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Felipe Sierra, PhD

Hevolution Foundation

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Riyadh

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Saudi Arabia

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Jeremy Van Raamsdonk, PhD, MSc

Research Institute of the McGill University Health Centre, Montreal

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Quebec

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Canada

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Jennifer Watt, MD, PhD

Department of Critical Care Medicine, Sunnybrook Health Sciences Centre

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Toronto, Ontario

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Canada

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Rebecca Jane Rylett, PhD

Department of Physiology and Pharmacology, Western University

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London, Ontario

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Canada

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Gustavo Duque, MD, PhD, FRACP, FGSA

Department of Medicine, McGill University and Research Institute of the McGill University Health Centre

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Montréal, Québec

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Canada

Schouela Centre of Excellence for Sustainable Health of Seniors (Schouela CEDurable)

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Montreal, Québec

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Canada

Address correspondence to: Gustavo Duque, MD, PhD, FRACP, FGSA. E-mail: gustavo.duque@mcgill.ca

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The Journals of Gerontology: Series A, Volume 79, Issue 7, July 2024, glae069, https://doi.org/10.1093/gerona/glae069

Published:

15 March 2024

Article history

Received:

03 January 2024

Editorial decision:

21 February 2024

Published:

15 March 2024

Corrected and typeset:

12 June 2024

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    Guy Hajj-Boutros, Andréa Faust, John Muscedere, Perry Kim, Naji Abumrad, Stéphanie Chevalier, Mylene Aubertin-Leheudre, Howard Bergman, Dawn Bowdish, Jessica Burford, Stacy Carrington-Lawrence, Hélène Côté, David E Dawe, Philipe de Souto Barreto, Colin Farrelly, Robert Fowler, Gilles Gouspillou, Lea Harrington, Sofie Lautrup, Susan Howlett, Mahdi Imani, James Kirkland, George Kuchel, Frédérick A Mallette, José A Morais, John C Newman, Daryl Pullman, Felipe Sierra, Jeremy Van Raamsdonk, Jennifer Watt, Rebecca Jane Rylett, Gustavo Duque, Navigating the Landscape of Translational Geroscience in Canada: A Comprehensive Evaluation of Current Progress and Future Directions, The Journals of Gerontology: Series A, Volume 79, Issue 7, July 2024, glae069, https://doi.org/10.1093/gerona/glae069

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Abstract

The inaugural Canadian Conferences on Translational Geroscience were held as 2 complementary sessions in October and November 2023. The conferences explored the profound interplay between the biology of aging, social determinants of health, the potential societal impact of geroscience, and the maintenance of health in aging individuals. Although topics such as cellular senescence, molecular and genetic determinants of aging, and prevention of chronic disease were addressed, the conferences went on to emphasize practical applications for enhancing older people’s quality of life. This article summarizes the proceeding and underscores the synergy between clinical and fundamental studies. Future directions highlight national and global collaborations and the crucial integration of early-career investigators. This work charts a course for a national framework for continued innovation and advancement in translational geroscience in Canada.

Aging, Animal studies, Clinical trials, Geroscience, Translational Research

© The Author(s) 2024. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)

Issue Section:

The Journal of Gerontology: BIOLOGICAL SCIENCES > Translational Geroscience > Invited Contribution

Decision Editor: Rafael de Cabo, PhD, FGSA (Biological Sciences Section)

Rafael de Cabo, PhD, FGSA (Biological Sciences Section)

Decision Editor

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Navigating the Landscape of Translational Geroscience in Canada: A Comprehensive Evaluation of Current Progress and Future Directions (2024)

FAQs

What is the Canadian translational Geroscience network? ›

The Canadian Translational Geroscience Network is a network that focuses on understanding and applying geroscience principles to enhance the health and well-being of aging populations across Canada.

How will the aging of the Canadian population impact Canadian policies in the future? ›

It is widely recognized that the aging of the population will greatly strain Canadian prov- incial governments' budgets, with health-care expenditures projected to rapidly increase as the share of the population over age 65 increases in the coming decades (Fuss and Li, 2021; Tombe, 2022).

What is the Canadian Longitudinal Study on Aging? ›

The Canadian Longitudinal Study on Aging (CLSA) is a national longitudinal study of adult development and aging that will recruit 50,000 Canadians aged 45 to 85 years of age and follow them for at least 20 years.

What is translational Geroscience a new paradigm for 21st century medicine? ›

The goal of translational geroscience is to apply results like those achieved with rapamycin in laboratory animals in order to maximize healthspan for people. Optimally, this would yield longer lifespans, but more importantly, lifespans that are largely spent disease free, with youthful vigor.

What is the major problem with Canada's aging population structure? ›

A decreasing ratio of working-age people-to-seniors is affecting government revenue and expenditures in ways that are already straining government finances and has been a major contributing factor in a long-term decline in the labour force participation rate.

What is the significant contributing factor to Canada's aging population? ›

One of the main causes of the aging of the Canadian population is the change in fertility rates since 1945. The fertility rate was three children or more per woman from the mid-1940s to the mid-1960s.

How will Canada's aging population affect the people available to work? ›

There will likely be more Canadians leaving the workforce than entering it over the next few decades as the country's senior population grows, according to new data from Statistics Canada. Experts say this will not only exacerbate existing labour shortages, but could result in higher wages for employees.

What is CNCS in Canada? ›

Corporation for National and Community Service - CNCS.

What is the Canadian Association of Translation Studies? ›

The Canadian Association for Translation Studies (CATS) [fr: Association canadienne de traductologie] is a Canadian non-profit organization that promotes research on translation, writing, terminology, and interpretation.

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Welcome to the Canadian Network on Humanitarian History

We are a multidisciplinary network interested in the history of humanitarian and development aid, NGOs, and the archives that preserve the histories of organizations and institutions related to this history.

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